Hotels in Big Bend Scenic Byway

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Where to stay in Big Bend Scenic Byway?

The Panacea Motel
Exterior

The Panacea Motel

2.0 star property
9.0 out of 10, Wonderful, (75)
The price is $133
includes taxes & fees
$119 per night
Apr 28 - Apr 29
The Panacea Motel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Big Bend Scenic Byway

Big Bend Scenic Byway is well-known for its attractions such as Ochlockonee River State Park and Apalachicola National Forest.

See all hotels in Big Bend Scenic Byway
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

Can I book a refundable hotel in Big Bend Scenic Byway?
If you’re looking for the flexibility to change your plans to Big Bend Scenic Byway, most hotels provide refundable* bookable rates. You can see these properties by searching our site and using the “fully refundable” filter to narrow the results down.
Where can I stay in Big Bend Scenic Byway if I want a vacation rental instead of a traditional hotel?
If you’re looking for a good alternative to a hotel, look over our selection of 22 vacation homes. You also might want to book one of 8 condos for your trip.
Why should I book my Big Bend Scenic Byway accommodation with Hotels.com?
There are lots of reasons to book your Big Bend Scenic Byway trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

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