Hotels in South Carolina Lowcountry

Free cancellation options if plans change
Unlock travel rewards with One Key
Save more with Member Prices

Check prices for these dates

Tonight
May 11 - May 12
Tomorrow
May 12 - May 13
Next weekend
May 16 - May 18
In two weeks
May 23 - May 25

Where to stay in South Carolina Lowcountry?

Red Roof Inn Yemassee
Lobby

Red Roof Inn Yemassee

2.0 star property
7.6 out of 10, Good, (546)
$74 nightly
The price is $81
May 12 - May 13
Total includes taxes and fees
Red Roof Inn Yemassee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in South Carolina Lowcountry, SC

Showing deals for:May 23 - May 25

Image gallery for Marriott's Barony Beach Club

Bar (on property)

Marriott's Barony Beach Club

3.5 star property
Hilton Head Island
9.4/10Exceptional (236 reviews)
15% off
Price is $1,924
$875 nightly
$1,924 total
Total includes taxes and fees
Marriott's Barony Beach Club

Top neighborhoods in South Carolina Lowcountry

Default Image

Sea Pines

Hilton Head Island's Sea Pines neighborhood has a host of places to visit such as Atlantic Dunes by Davis Love III and Harbour Town Golf Links.

See properties in Sea Pines
Sea Pines

Top landmarks in South Carolina Lowcountry

Marine Corps Recruit Depot Parris Island

Marine Corps Recruit Depot Parris Island

Marine Corps Recruit Depot Parris Island is worth a visit, located 0.6 mi (0.9 km) from central Parris Island. Hotels.com travelers also say the area is family-friendly and has lots of nice beaches.

See properties in Marine Corps Recruit Depot Parris Island
Marine Corps Recruit Depot Parris Island

Learn more about South Carolina Lowcountry

South Carolina Lowcountry is applauded for its cultural attractions such as Highway 21 Drive-In Theater and The Forde Doll & Doll House Collection.

See all hotels in South Carolina Lowcountry
Hilton Head featuring heritage architecture
Photo by Hilton Head Island Visitor & Convention Bureau
Open Photo by Hilton Head Island Visitor & Convention Bureau
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
Sign in or join for free

Frequently asked questions

What hotels do travelers recommend in South Carolina Lowcountry?
The Inn & Club at Harbour Town, Montage Palmetto Bluff and Hilton Grand Vacations Club Ocean Oak Resort Hilton Head are all properties that our guests really like.
Can I book refundable hotels in South Carolina Lowcountry?
If you want the flexibility to change your travel plans to South Carolina Lowcountry, most hotels provide refundable* bookable rates. You can find these properties by searching our site and using the “fully refundable” filter to narrow down the results.
Which South Carolina Lowcountry hotels do our guests like for their terrific location?
Our guests love these properties for their convenient location: Beach House Resort Hilton Head, Microtel Inn & Suites by Wyndham Walterboro and Quality Inn At Town Center.
Where should I consider staying in South Carolina Lowcountry if I'm looking for a budget-friendly accommodation?
Best Western Plus Hardeeville Inn & Suites, Microtel Inn & Suites by Wyndham Walterboro and Red Roof Inn Hardeeville are a few accommodations you might want to consider that’ll save you money. You may want to browse more choices on our site, including 17 motels.
Where can I stay in South Carolina Lowcountry if I want a vacation home instead of a hotel?
If you want to find a good alternative to a hotel, review our selection of 4188 vacation homes. In addition, there are 225 apartments and 3043 condos.
Why should I book my South Carolina Lowcountry accommodation with Hotels.com?
There are lots of reasons to book your South Carolina Lowcountry trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

https://www.hotels.com/lp/b/deals