21c Museum Hotel Louisville

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Reviews

9.4 out of 10, Loved by guests
Top-rated by travelers

Artful nights in Bourbon Country

In historic downtown Louisville, this 24/7 contemporary art museum hotel keeps the lobby hush-and-hum feeling like a gallery opening that never ends. Minimalist, industrial-chic spaces show off exposed brick, timber columns, and hardwood floors, with playful red penguins posted as friendly sentries. Downstairs, Proof on Main brings the social current with a lively lounge pour and a menu built around the Ohio River Valley’s flavors.

  • Museum Row address

    Steps from Louisville Slugger Museum and the Muhammad Ali Center.

  • Dining with a point of view

    Proof on Main reworks Southern and Appalachian classics with global technique.

  • Curated bourbon pairing flights

    The 21c Selects program matches special picks with desserts.
$173 nightly
The total price is $204
Oct 25 - Oct 26
Total with taxes and fees

Amenities

  • Nightly Nightcap at the Museum bourbon sip
  • Sip & Tour with an art-inspired cocktail
  • 9,000 square feet of rotating exhibitions
  • In-room Malin+Goetz bath amenities
  • Lavazza or Nespresso coffee machines in rooms
  • 24-hour fitness center for any schedule
These property details are summarized by AI

Why we love this property

Work and play paradise
Located in the city center's business district, this hotel offers a 24-hour business center and meeting rooms. Guests can unwind at the full-service spa or bar.
Dining that delights
This hotel tantalizes taste buds with a restaurant, bar, and full breakfast offerings. Culinary adventures await morning through evening.

Room options

Available filters for rooms
Showing 12 of 12 rooms

View all photos for Deluxe Double Room, 2 Double Beds

A hotel room with two beds, a headboard with a framed artwork of birds, a bedside table with a lamp, and a small bookshelf.

Deluxe Double Room, 2 Double Beds

9.6 out of 10
Exceptional
(34 reviews)
  • 335 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Double Beds
  • Free wired internet

View all photos for Luxury Double Room, 2 Double Beds

A hotel room with two beds, a desk, a chair, a lamp, and a large window with a view.

Luxury Double Room, 2 Double Beds

  • City view
  • 435 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Double Beds
  • Free wired internet

View all photos for Deluxe Room, 1 King Bed

A hotel room with a bed, a desk, a chair, a lamp, a plant, and a TV on the wall.

Deluxe Room, 1 King Bed

9.6 out of 10
Exceptional
(79 reviews)
  • 350 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed
  • Free wired internet

View all photos for Luxury Room, 1 King Bed

A hotel room with a large bed, a chair, a desk, and a window with curtains.

Luxury Room, 1 King Bed

9.0 out of 10
Wonderful
(37 reviews)
  • City view
  • 455 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed
  • Free wired internet

View all photos for Suite, Corner

A modern living room with a grey sofa, a red decorative piece, a white armchair, and a dining area with a table and chairs.

Suite, Corner

  • City view
  • 660 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free wired internet

View all photos for Room (Asleep in the Cyclone)

A room with a geometric-patterned ceiling, a bed with a patterned bedspread, and a nightstand with a lamp.

Room (Asleep in the Cyclone)

  • 500 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free wired internet

View all photos for Suite (Atrium)

A hotel room with a bed, desk, chair, dresser, and a sofa.

Suite (Atrium)

  • 580 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free wired internet

View all photos for Room, Balcony

A hotel room with a large bed, a nightstand with a lamp, a chair, and a view of the outdoors.

Room, Balcony

10.0 out of 10
Exceptional
(1 review)
  • City view
  • 315 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free wired internet

View all photos for Deluxe Double Room, Accessible

A modern bathroom with a white sink, mirror, and toilet.

Deluxe Double Room, Accessible

9.0 out of 10
Wonderful
(2 reviews)
  • 455 sq ft
  • Sleeps 4
  • 2 Double Beds
  • Free wired internet

View all photos for Deluxe Room, 1 King Bed, Accessible

A hotel room with a large bed, two bedside tables with lamps, a wooden headboard, a large mirror, and a wall-mounted abstract art piece.

Deluxe Room, 1 King Bed, Accessible

10.0 out of 10
Exceptional
(2 reviews)
  • 434 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free wired internet

View all photos for Deluxe Room, 1 King Bed, Accessible

A hotel room with a large bed, two bedside tables with lamps, a wooden headboard, a large mirror, and a wall-mounted abstract art piece.

Deluxe Room, 1 King Bed, Accessible

10.0 out of 10
Exceptional
(1 review)
  • 435 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free wired internet

View all photos for Apartment, 1 Double Bed (Rooftop)

A modern interior with a dining area, a patterned bench, and a large window with a city view.

Apartment, 1 Double Bed (Rooftop)

10.0 out of 10
Exceptional
(1 review)
  • City view
  • Sleeps 4
  • 1 Double Bed
  • Free wired internet

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$145 nightly
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Total with taxes and fees
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About the neighborhood

Map
700 W Main Street, Louisville, KY, 40202

What's nearby

  • 21c Museum Hotel - 1 min walk - 0.1 km
  • Muhammad Ali Center - 3 min walk - 0.3 km
  • Louisville Slugger Museum - 3 min walk - 0.3 km
  • Kentucky International Convention Center - 8 min walk - 0.7 km
  • KFC Yum Center - 8 min walk - 0.7 km

Getting around

  • Louisville Intl. Airport (SDF) - 10 min drive

Restaurants

  • ‪Thelma's Deli - ‬7 min walk
  • ‪Steak And Bourbon - ‬7 min walk
  • ‪Heine Brothers' Coffee - ‬3 min walk
  • ‪Swizzle - ‬7 min walk
  • ‪Loft At The Biscuit Lounge - ‬7 min walk

About this property

21c Museum Hotel Louisville

  • 21c Museum Hotel Louisville offers a great location, putting you within just a 10-minute walk of Louisville Slugger Museum and KFC Yum Center. Guests can indulge in deep-tissue massages at the spa, and Proof on Main serves breakfast, lunch, and dinner. This luxurious hotel also features a bar/lounge, a 24-hour fitness center, and a fitness center. Fellow travelers love the helpful staff and restaurant.

At a glance

Hotel size

    • 91 rooms
    • Arranged over 4 floors

Arriving/Leaving

    • Check-in start time: 4 PM; Check-in end time: midnight
    • Contactless check-in available
    • Minimum check-in age: 21
    • Check-out time is 11 AM
    • Contactless check-out available

Special check-in instructions

    • Front desk staff will greet guests on arrival at the property
    • Information provided by the property may be translated using automated translation tools

Required at check-in

    • Credit card required for incidental charges
    • Government-issued photo ID may be required
    • Minimum check-in age is 21

Pets

    • Pets allowed (up to 50 lbs per pet)*
    • Service animals welcome
    • Food and water bowls available

Internet

    • Free WiFi and wired internet access in public areas
    • Free WiFi and wired internet access in rooms

Parking

    • Onsite valet parking (USD 32 per night; includes in/out privileges)
    • Wheelchair-accessible parking on site
    • Electric vehicle charging point on site

Other information

    • Smoke-free property

Property amenities

Food and drink

  • Full breakfast (surcharge) 7:00 AM–10:00 AM on weekdays and 8:00 AM–1:00 PM on weekends
  • Restaurant
  • Bar/lounge
  • Coffee/tea in a common area
  • Room service (limited hours)

What to do

  • Yoga classes
  • Golfing nearby
  • Hiking/biking trails nearby

Working away

  • 24-hour business center
  • Meeting rooms
  • Computer station
  • Conference space (5000 square feet)

Services

  • 24-hour front desk
  • Concierge services
  • Tour/ticket assistance
  • Limo or town car service
  • Dry cleaning/laundry services
  • Luggage storage
  • Multilingual staff
  • Porter/bellhop

Facilities

  • 1 building/tower
  • Built in 2006
  • ATM/banking
  • Safe-deposit box at front desk
  • 24-hour fitness center
  • Full-service spa
  • Massage/treatment rooms
  • Vegan dining options
  • Double-glazed windows
  • Uses some LED lighting
  • Comprehensive food waste policy
  • No plastic soda bottles
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic water bottles
  • Reusable cups only
  • Reusable tableware only
  • Banquet hall

Accessibility

  • Wheelchair accessible
  • Braille/raised signage
  • Elevator
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible parking
  • Assistive listening devices available
  • Wheelchair-accessible registration desk

Room amenities

Be entertained

  • 50-inch LCD TV
  • Premium cable channels

Home comfort

  • Air conditioning (climate-controlled)
  • Minibar
  • Espresso maker
  • Bathrobes
  • Iron/ironing board

Sleep well

  • Hypo-allergenic bedding
  • Down comforter
  • Blackout drapes/curtains
  • Soundproofed rooms
  • Premium bedding
  • Free crib/infant bed
  • Rollaway/extra bed (surcharge)

What to enjoy

  • In-room massage

Freshen up

  • Private bathroom
  • Designer toiletries
  • Hair dryer
  • Towels
  • Toothbrush and toothpaste (on request)
  • Toilet paper

Stay connected

  • Desk
  • Free WiFi and wired internet
  • Free local calls

Food and drink

  • Champagne service
  • Free bottled water

More

  • Daily housekeeping
  • In-room safe (laptop compatible)
  • Connecting/adjoining rooms available
  • Eco-friendly toiletries
  • Eco-friendly cleaning products provided
  • Uses some LED lighting
  • Water-efficient showers only

Special features

Spa

21c Spa has 2 treatment rooms. Services include deep-tissue massages, hot stone massages, sports massages, and Swedish massages. The spa is equipped with a sauna and a steam room. The spa is open daily.

Dining

Proof on Main - This fine-dining restaurant serves breakfast, brunch, lunch, and dinner. Guests can enjoy drinks at the bar. Open daily.

Awards and affiliations

Sustainability Certifications
This property is certified by this third-party sustainability certification scheme: Green Key Global. For more information on what this certification requires and verifies, please visit their website.

Fees & policies

Mandatory fees

You'll be asked to pay the following charges by the property at check-in or check-out. Fees may include applicable taxes:
  • Service fee: USD 5.00 per accommodation, per stay

Optional extras

  • Full breakfast is offered for an extra charge of approximately USD 5 to 25 per person

Children & extra beds

  • Rollaway beds are available for USD 30.0 per night

Pets

  • Service animals exempt from fees
  • Pets are allowed for an extra charge of USD 40.00 per accommodation, per stay

Parking

  • Valet parking costs USD 32 per night with in/out privileges

Pool, spa, & gym (if applicable)

  • Reservations are required for massage services and can be made by contacting the property before arrival at the number on the booking confirmation

Policies

Extra-person charges may apply and vary depending on property policy.
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
Guests can rest easy knowing there's a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards on site.
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation.
This property accepts credit cards. Cash is not accepted.
Credit cards accepted: Visa, Mastercard, American Express, Discover
This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels).

Also known as

21c Hotel Louisville
21c Hotel Museum
21c Louisville Hotel
21c Museum
21c Museum Hotel
21c Museum Hotel Louisville
21c Museum Louisville
Louisville 21c Hotel
Louisville 21c Museum
Museum Hotel 21c
21c Museum Hotel Louisville MGallery
21c Museum Louisville MGallery
Hotel 21c Museum Hotel Louisville - MGallery Louisville
Louisville 21c Museum Hotel Louisville - MGallery Hotel
21c Museum Hotel Louisville - MGallery Louisville
Hotel 21c Museum Hotel Louisville - MGallery
21c Museum Hotel MGallery
21c Museum MGallery
21c Museum Hotel Louisville
21c Museum Louisville Mgallery
21c Museum Louisville
21c Museum Hotel Louisville Hotel
21c Museum Hotel Louisville MGallery
21c Museum Hotel Louisville Louisville
21c Museum Hotel Louisville Hotel Louisville

Frequently asked questions

Does 21c Museum Hotel Louisville offer free cancellation for a full refund?

Yes, 21c Museum Hotel Louisville does have fully refundable room rates available to book on our site. If you’ve booked a fully refundable room rate, this can be cancelled up to a few days before check-in depending on the property's cancellation policy. Just make sure to check this property's cancellation policy for the exact terms and conditions.

Are pets allowed at 21c Museum Hotel Louisville?

Yes, pets are welcome, with a maximum weight of 50 lbs per pet. There's a charge of USD 40.00 per accommodation, per stay. Service animals are exempt from fees. Food and water bowls are available.

Is parking offered on site at 21c Museum Hotel Louisville?

Yes. Valet parking costs USD 32 per night. Electric vehicle charging is available.

What are the check-in and check-out times at 21c Museum Hotel Louisville?

Check-in start time: 4 PM; Check-in end time: midnight. Check-out time is 11 AM. Contactless check-in and check-out are available.

Is there an onsite casino at 21c Museum Hotel Louisville?

No, this hotel doesn't have a casino, but Horseshoe Southern Indiana Casino (22-min drive) is nearby.

What is there to do at 21c Museum Hotel Louisville and nearby?

Have fun with nearby activities such as hiking and practice your swing at the nearby golf course. Additional recreation onsite includes yoga. Indulge in a treatment at the spa and enjoy other amenities such as a 24-hour fitness center and spa services.

Are there restaurants at or near 21c Museum Hotel Louisville?

Yes, there's an onsite restaurant, Proof on Main.

What's the area around 21c Museum Hotel Louisville like?

21c Museum Hotel Louisville is in Downtown Louisville, a short 10-minute drive from Louisville Intl. Airport (SDF) and 3 minutes' walk from Louisville Slugger Museum. Travelers say that the hotel is in a great location.

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Reviews

21c Museum Hotel Louisville Reviews

9.4

Exceptional

9.6

Cleanliness

9.0

Amenities

9.4

Staff & service

9.6

Property conditions & facilities

Guest review summary

What guests liked

  • The on-site restaurant was consistently described as excellent, delicious, and great. (61 reviews)
  • Valet parking was convenient and self-parking was available nearby at a reasonable price. (13 reviews)
  • Breakfast was a good value and great at this property. (4 reviews)
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From real guest reviews summarized by AI.
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Popular mentions

Room
Service staff
Art
Restaurant
Location
Bed
Museums
Bar
Food
Bathroom

Reviews

Verified review

10/10 Exceptional

Very nice hotel next to the bourbon trail. Staff were very friendly and helpful. Would definitely stay again if visiting Louisville.
Verified review

10/10 Exceptional

We love 21C, whenever we travel that is our first go to hotel. We have one in our hometown and love what it offers and the rooms are phenomenal
Verified review

8/10 Very good

This is a very nice hotel, with clean comfortable rooms and plush beds. Front desk was very helpful with local recommendations. I liked the quirkiness of the property, but the overall vibe is definitely more 'adult'. Our kids loved the screen by the elevators, but the other art was a bit off-putting for younger families. Also, there was plenty of room in there to make those beds queen-sized!
Verified review

10/10 Exceptional

Room was nice. Staff was helpful. Restaurant was excellent.
Verified review

10/10 Exceptional

Loved this hotel and museum. Really enjoyed leisurely walking the museum with a bourbon in hand!
Verified review

10/10 Exceptional

The hotel is quite unique with the art displayed throughout and the rooms are very well appointed with comfortable beds
Verified review

10/10 Exceptional

Very cool hotel with an art studio within it. Great staff. Great location. Great room and amenities.
Verified review

10/10 Exceptional

Lovely experience, room was beautiful, clean, comfortable; staff was welcoming. Hotel was just lovely. We would definitely go back and highly recommend it to other travelers.
Verified review

10/10 Exceptional

Stayed there for thunder and it was so pleasant! Quiet and comfortable. All staff was very helpful and the cleanliness of the entire hotel was amazing!
Verified review

10/10 Exceptional

Nice room and close to all the distilleries. Great restaurant on site as well!
Verified review

10/10 Exceptional

Great hotel And staff. Will come. Back
Verified review

10/10 Exceptional

Great museum themed hotel with character. The rooms were spacious and comfortable. Also located right of bourbon row which makes it easy to get around town. The valet service and staff were courteous and helpful. They can also charge your electric vehicle, which is included with your stay, while the car is parked.
Verified review

10/10 Exceptional

Large spacious room and super comfortable bed Fascinating art and super bar and restaurant too Great service from all staff
Verified review

10/10 Exceptional

Unique venue with some many amenities. Staff are super helpful and hospital. Will stay again when I’m in town.
Verified review

10/10 Exceptional

Great room, super kind staff
Verified review

10/10 Exceptional

The rooms and staff were great and the penguins were alive.
Verified review

10/10 Exceptional

Very clean and quiet room
Verified review

10/10 Exceptional

Very clean and beautiful artwork, friendly I was surprised in the morning with valet parking with them overnight cane surprise charge if my Tesla , which is wonderful
Verified review

10/10 Exceptional

21C is by far the best hotel we’ve ever stayed in. The museum is fantastic! The entire Staff went above and beyond for us.
Verified review

10/10 Exceptional

Clean room, art work is beautiful, friendly staff .
Verified review

10/10 Exceptional

Interesting Ambiente, very knowledgeable and friendly staff, great bar and good food in the restaurant with special choices.
Verified review

8/10 Very good

Great location for Whiskey Row in Downtown Louisville. Hotel was clean, artsy and has a great restaurant on site.
Verified review

10/10 Exceptional

All the staff were great! The rooms were clean the coffee was great. I would stay here again.
Verified review

10/10 Exceptional

Staff was very kind, the art was fantastic, location was perfect to explore Whiskey Row, and we had a gorgeous room. Loved our time away there!
Verified review

10/10 Exceptional

clean rooms, outgoing and friendly staff. The vibe is warm and fun, love the penguins