21c Museum Hotel Louisville

Luxury hotel with spa, near Louisville Slugger Museum

Choose dates to view prices

Sat, Mar 28
Sun, Mar 29
March 2026
14
April 2026
Unwind in the heart of Louisville at 21c Museum Hotel Louisville, where art and luxury meet. Treat yourself to a rejuvenating massage at the onsite spa, then enjoy breakfast or dinner at Proof on Main. With a 24-hour gym, dry cleaning services, and helpful staff by your side.
Exceptional

Popular amenities

  • Spa
  • Pet friendly
  • Free WiFi
  • Connecting rooms available

Main amenities (12)

  • Daily housekeeping
  • Restaurant and bar/lounge
  • Full-service spa
  • Breakfast available
  • 24-hour fitness center
  • Valet parking
  • Room service
  • Massage/treatment rooms
  • 24-hour business center
  • Business center
  • Meeting rooms
  • Limo/town car service

Feel at home (6)

  • Free cribs/infant beds
  • Connecting/adjoining rooms available
  • Private bathroom
  • Premium TV channels
  • Daily housekeeping
  • Laundry facilities
$183 nightly
$216 total
Mar 19 - Mar 20
Total with taxes and fees

Why we love this property

City center views
This boutique luxury hotel boasts breathtaking city panoramas, putting guests in the heart of urban vibrancy. Elegant design meets metropolitan charm.
Dining that delights
This hotel tantalizes taste buds with a restaurant, bar, and full breakfast offerings. Culinary adventures await morning through evening.
Luxury sleep retreat
Bathrobes, premium bedding, and hypo-allergenic comfort create a sumptuous sanctuary. The turndown service adds a final touch to this lavish sleep experience.

Room options

Showing 12 of 12 rooms
Designer toiletries, hair dryer, bathrobes, towels
Deluxe Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe
Designer toiletries, hair dryer, bathrobes, towels
Deluxe Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Deluxe Double Room, 2 Double Beds

Exceptional

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Down duvet
Blackout drapes/curtains
  • 335 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Double Beds
Designer toiletries, hair dryer, bathrobes, towels
Luxury Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe
Designer toiletries, hair dryer, bathrobes, towels
Luxury Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Luxury Double Room, 2 Double Beds

Wonderful

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Down duvet
Blackout drapes/curtains
  • City view
  • 435 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Double Beds
Designer toiletries, hair dryer, bathrobes, towels
Deluxe Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe
Premium bedding, down comforters, minibar, in-room safe
Designer toiletries, hair dryer, bathrobes, towels

Deluxe Room, 1 King Bed

Exceptional

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Down duvet
Blackout drapes/curtains
  • 350 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed
Designer toiletries, hair dryer, bathrobes, towels
Luxury Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe
Designer toiletries, hair dryer, bathrobes, towels
Luxury Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe

Luxury Room, 1 King Bed

Wonderful

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Down duvet
Blackout drapes/curtains
  • City view
  • 455 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed
Suite, Corner | Bathroom | Designer toiletries, hair dryer, bathrobes, towels
Suite, Corner | Premium bedding, down comforters, minibar, in-room safe
Suite, Corner | Premium bedding, down comforters, minibar, in-room safe
Suite, Corner | Bathroom | Designer toiletries, hair dryer, bathrobes, towels

Suite, Corner

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Down duvet
Premium bedding
  • City view
  • 660 sq ft
  • Sleeps 3
  • 1 King Bed
Room (Asleep in the Cyclone) | Bathroom | Designer toiletries, hair dryer, bathrobes, towels
Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe
Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe
Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe

Room (Asleep in the Cyclone)

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Down duvet
Premium bedding
  • 500 sq ft
  • Sleeps 3
  • 1 King Bed
Suite (Atrium) | Bathroom | Designer toiletries, hair dryer, bathrobes, towels
Suite (Atrium) | Premium bedding, down comforters, minibar, in-room safe
Suite (Atrium) | Premium bedding, down comforters, minibar, in-room safe
Suite (Atrium) | Bathroom | Designer toiletries, hair dryer, bathrobes, towels

Suite (Atrium)

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Down duvet
Premium bedding
  • 580 sq ft
  • Sleeps 3
  • 1 King Bed
Room, Balcony | Bathroom | Designer toiletries, hair dryer, bathrobes, towels
Room, Balcony | Premium bedding, down comforters, minibar, in-room safe
Room, Balcony | Terrace/patio
Room, Balcony | Bathroom | Designer toiletries, hair dryer, bathrobes, towels

Room, Balcony

Exceptional

Highlights

Furnished balcony or patio
Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Down duvet
  • City view
  • 315 sq ft
  • Sleeps 3
  • 1 King Bed
Designer toiletries, hair dryer, bathrobes, towels
Designer toiletries, hair dryer, bathrobes, towels
Designer toiletries, hair dryer, bathrobes, towels
Designer toiletries, hair dryer, bathrobes, towels

Deluxe Double Room, Accessible

Wonderful

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Down duvet
Premium bedding
  • 455 sq ft
  • Sleeps 4
  • 2 Double Beds
Designer toiletries, hair dryer, bathrobes, towels
Premium bedding, down comforters, minibar, in-room safe
Designer toiletries, hair dryer, bathrobes, towels
Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

Exceptional

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Down duvet
Premium bedding
  • 434 sq ft
  • Sleeps 3
  • 1 King Bed
Designer toiletries, hair dryer, bathrobes, towels
Premium bedding, down comforters, minibar, in-room safe
Designer toiletries, hair dryer, bathrobes, towels
Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

Exceptional

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Down duvet
Premium bedding
  • 435 sq ft
  • Sleeps 3
  • 1 King Bed
Apartment, 1 Double Bed (Rooftop) | Private kitchen | Espresso maker, eco-friendly cleaning products
Apartment, 1 Double Bed (Rooftop) | Premium bedding, down comforters, minibar, in-room safe
Apartment, 1 Double Bed (Rooftop) | Premium bedding, down comforters, minibar, in-room safe
Apartment, 1 Double Bed (Rooftop) | Premium bedding, down comforters, minibar, in-room safe

Apartment, 1 Double Bed (Rooftop)

Highlights

Furnished balcony or patio
Soundproofed
Air conditioning
Connecting rooms available
Free cribs/infant beds
HDTV
Hypo-allergenic bedding
Down duvet
  • City view
  • Sleeps 4
  • 1 Double Bed

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About the neighborhood

Map
700 W Main Street, Louisville, KY, 40202

What's nearby

  • 21c Museum Hotel - 1 min walk - 0.0 km
  • Muhammad Ali Center - 3 min walk - 0.3 km
  • Louisville Slugger Museum - 3 min walk - 0.3 km
  • Kentucky International Convention Center - 8 min walk - 0.7 km
  • KFC Yum Center - 8 min walk - 0.7 km

Getting around

  • Louisville Intl. Airport (SDF) - 10 min drive
  • Louisville, KY (LOU-Bowman Field) - 11 min drive

Restaurants

  • ‪Jockey Silks Bourbon Bar - ‬7 min walk
  • ‪Heine Brothers' Coffee - ‬3 min walk
  • ‪Vincenzo's Italian Restaurant - ‬5 min walk
  • ‪Swizzle - ‬8 min walk
  • ‪Sunergos Coffee and Espresso Bar - ‬6 min walk

About this property

21c Museum Hotel Louisville

21c Museum Hotel Louisville offers a great location, putting you within just a 10-minute walk of Louisville Slugger Museum and KFC Yum Center. Guests can indulge in deep-tissue massages at the spa, and Proof on Main serves breakfast, lunch, and dinner. This luxurious hotel also features a bar/lounge, a 24-hour fitness center, and a fitness center. Fellow travelers love the helpful staff and restaurant.

At a glance

Hotel size

    • 91 rooms
    • Arranged over 4 floors

Arriving/Leaving

    • Check-in start time: 4 PM; Check-in end time: midnight
    • Contactless check-in available
    • Minimum check-in age: 21
    • Check-out time is 11 AM
    • Contactless check-out available

Special check-in instructions

    • Front desk staff will greet guests on arrival at the property
    • Information provided by the property may be translated using automated translation tools

Required at check-in

    • Credit card required for incidental charges
    • Government-issued photo ID may be required
    • Minimum check-in age is 21

Pets

    • Pets allowed (up to 50 lbs per pet)*
    • Service animals welcome
    • Food and water bowls available

Internet

    • Free WiFi and wired internet access in public areas
    • Free WiFi and wired internet access in rooms

Parking

    • Onsite valet parking (USD 32 per night; includes in/out privileges)
    • Wheelchair-accessible parking on site
    • Electric vehicle charging point on site

Other information

    • Smoke-free property

Property amenities

Food and drink

  • Full breakfast (surcharge) 7:00 AM–10:00 AM on weekdays and 8:00 AM–1:00 PM on weekends
  • Restaurant
  • Bar/lounge
  • Coffee/tea in a common area
  • Room service (limited hours)

What to do

  • Yoga classes
  • Golfing nearby
  • Hiking/biking trails nearby

Working away

  • 24-hour business center
  • Meeting rooms
  • Computer station
  • Conference space (5000 square feet)

Services

  • 24-hour front desk
  • Concierge services
  • Tour/ticket assistance
  • Limo or town car service
  • Dry cleaning/laundry services
  • Luggage storage
  • Multilingual staff
  • Porter/bellhop

Facilities

  • 1 building/tower
  • Built in 2006
  • ATM/banking
  • Safe-deposit box at front desk
  • 24-hour fitness center
  • Full-service spa
  • Massage/treatment rooms
  • Vegan dining options
  • Double-glazed windows
  • At least 80% lighting from LEDs
  • Comprehensive food waste policy
  • No plastic soda bottles
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic water bottles
  • Reusable cups only
  • Reusable tableware only
  • Banquet hall

Accessibility

  • Wheelchair accessible
  • Braille/raised signage
  • Elevator
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible parking
  • Assistive listening devices available
  • Wheelchair-accessible registration desk

Room amenities

Be entertained

  • 50-inch LCD TV
  • Premium cable channels

Home comfort

  • Air conditioning (climate-controlled)
  • Minibar
  • Espresso maker
  • Bathrobes
  • Iron/ironing board

Sleep well

  • Hypo-allergenic bedding
  • Down comforter
  • Blackout drapes/curtains
  • Soundproofed rooms
  • Premium bedding
  • Free crib/infant bed
  • Rollaway/extra bed (surcharge)

What to enjoy

  • In-room massage

Freshen up

  • Private bathroom
  • Designer toiletries
  • Hair dryer
  • Towels
  • Toothbrush and toothpaste (on request)
  • Toilet paper

Stay connected

  • Desk
  • Free WiFi and wired internet
  • Free local calls

Food and drink

  • Champagne service
  • Free bottled water

More

  • Daily housekeeping
  • In-room safe (laptop compatible)
  • Connecting/adjoining rooms available
  • Eco-friendly toiletries
  • Eco-friendly cleaning products provided
  • LED light bulbs
  • Water-efficient showers only

Special features

Spa

21c Spa has 2 treatment rooms. Services include deep-tissue massages, hot stone massages, sports massages, and Swedish massages. The spa is equipped with a sauna and a steam room. The spa is open daily.

Dining

Proof on Main - This fine-dining restaurant serves breakfast, brunch, lunch, and dinner. Guests can enjoy drinks at the bar.

Awards and affiliations

Eco-Certified Property
This property participates in Green Key Global, a program that measures the property's impact on one or more of the following: environment, community, cultural-heritage, the local economy.

Fees & policies

Mandatory fees

You'll be asked to pay the following charges by the property at check-in or check-out. Fees may include applicable taxes:
  • Service fee: USD 5.00 per accommodation, per stay

Optional extras

  • Full breakfast is offered for an extra charge of approximately USD 5 to 25 per person

Children & extra beds

  • Rollaway beds are available for USD 30.0 per night

Pets

  • Service animals exempt from fees
  • Pets are allowed for an extra charge of USD 40.00 per accommodation, per stay

Parking

  • Valet parking costs USD 32 per night with in/out privileges

Pool, spa, & gym (if applicable)

  • Reservations are required for massage services and can be made by contacting the property before arrival at the number on the booking confirmation

Policies

The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
This property uses eco-friendly cleaning products.
Guests can rest easy knowing there's a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards on site.
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation.
This property accepts credit cards. Cash is not accepted.
Credit cards accepted: Visa, Mastercard, American Express, Discover
This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels).

Also known as

21c Hotel Louisville
21c Hotel Museum
21c Louisville Hotel
21c Museum
21c Museum Hotel
21c Museum Hotel Louisville
21c Museum Louisville
Louisville 21c Hotel
Louisville 21c Museum
Museum Hotel 21c
21c Museum Hotel Louisville MGallery
21c Museum Louisville MGallery
Hotel 21c Museum Hotel Louisville - MGallery Louisville
Louisville 21c Museum Hotel Louisville - MGallery Hotel
21c Museum Hotel Louisville - MGallery Louisville
Hotel 21c Museum Hotel Louisville - MGallery
21c Museum Hotel MGallery
21c Museum MGallery
21c Museum Hotel Louisville
21c Museum Louisville Mgallery
21c Museum Louisville
21c Museum Hotel Louisville Hotel
21c Museum Hotel Louisville MGallery
21c Museum Hotel Louisville Louisville
21c Museum Hotel Louisville Hotel Louisville

Frequently asked questions

Does 21c Museum Hotel Louisville offer free cancellation for a full refund?

Yes, 21c Museum Hotel Louisville does have fully refundable room rates available to book on our site. If you’ve booked a fully refundable room rate, this can be cancelled up to a few days before check-in depending on the property's cancellation policy. Just make sure to check this property's cancellation policy for the exact terms and conditions.

Are pets allowed at 21c Museum Hotel Louisville?

Yes, pets are welcome, with a maximum weight of 50 lbs per pet. There's a charge of USD 40.00 per accommodation, per stay. Service animals are exempt from fees. Food and water bowls are available.

Is parking offered on site at 21c Museum Hotel Louisville?

Yes. Valet parking costs USD 32 per night. Electric vehicle charging is available.

What are the check-in and check-out times at 21c Museum Hotel Louisville?

Check-in start time: 4 PM; Check-in end time: midnight. Check-out time is 11 AM. Contactless check-in and check-out are available.

Is there an onsite casino at 21c Museum Hotel Louisville?

No, this hotel doesn't have a casino, but Horseshoe Southern Indiana Casino (22-min drive) is nearby.

What is there to do at 21c Museum Hotel Louisville and nearby?

Have fun with nearby activities such as hiking and practice your swing at the nearby golf course. Additional recreation onsite includes yoga. Indulge in a treatment at the spa and enjoy other amenities such as a 24-hour fitness center and spa services.

Are there restaurants at or near 21c Museum Hotel Louisville?

Yes, there's an onsite restaurant, Proof on Main.

What's the area around 21c Museum Hotel Louisville like?

21c Museum Hotel Louisville is in Downtown Louisville, a short 10-minute drive from Louisville Intl. Airport (SDF) and 3 minutes' walk from Louisville Slugger Museum. Travelers say that the hotel is in a great location.

Have a question?

Get instant answers with AI powered search of property information and reviews.

21c Museum Hotel Louisville Reviews

9.4

Exceptional

9.6

Cleanliness

7.6

Location

9.4

Staff & service

9.6

Property conditions & facilities

What guests liked

  • The on-site restaurant, Proof on Main, offers outstanding food and exceptional dining experience. (16 reviews)
  • Convenient valet parking and nearby self-parking options were available. (6 reviews)
  • Breakfast was a good value and a highlight of the stay. (6 reviews)
AI Sparkle IconFrom real guest reviews summarized by AI.

Popular mentions

RoomService staffArtRestaurantLocationMuseumsBedBarFoodBathroom

10/10 Exceptional

Great room and amenities.
Dean, 1-night trip

10/10 Exceptional

clean rooms, outgoing and friendly staff. The vibe is warm and fun, love the penguins
Douglas, 1-night trip

10/10 Exceptional

Fun hotel, lots of interesting art, very comfortable, excellent staff
Karen, 2-night trip

10/10 Exceptional

All the staff were great! The rooms were clean the coffee was great. I would stay here again.
Lorie, 2-night trip

10/10 Exceptional

Staff was very kind, the art was fantastic, location was perfect to explore Whiskey Row, and we had a gorgeous room. Loved our time away there!
Tammy, 1-night trip

10/10 Exceptional

Everything was great! We always love staying at the 21C!
Jeremy, 1-night trip

10/10 Exceptional

Art gallery was amazing
steven, 1-night trip

10/10 Exceptional

Loved our stay, would definitely plan to come back if we are ever in the area again.
Erica, 1-night trip

10/10 Exceptional

Great stay overall.
Jeannette, 2-night trip

10/10 Exceptional

Beautiful environment Helpful friendly staff
david, 1-night trip

10/10 Exceptional

The room was great! The bar was fantastic. The hotel accommodated all of my requests. My husband and I have stayed here a few times. I'm truly grateful for the kindness of the staff.
Kevin, 1-night trip

10/10 Exceptional

We only stayed 1 night, but everything was excellent
Shelley, 1-night trip

10/10 Exceptional

Room clean , comfortable and quiet.
Clark and Margaret, 1-night trip

10/10 Exceptional

Room was very clean and staff were very friendly.
Jennifer, 1-night trip

10/10 Exceptional

Excellent place to stay.
Thomas, 1-night trip

10/10 Exceptional

Excellent in every way. The art museum was an added bonus!!!
Jan Elliott, 3-night trip

10/10 Exceptional

21c Museum Hotel is a fun and unique experience. Beautiful rooms and centrally located to shops, restaurants and distilleries in Louisville.
Robin, 2-night trip

10/10 Exceptional

Amazing location and great hotel. Staff was great. Restaurant was delicious. Great location on Main Street!!
Jennifer, 4-night trip

10/10 Exceptional

Perfect location for walking Louisville
earl, 4-night trip

10/10 Exceptional

We had a great stay and very much enjoyed the art and the atmosphere.
Vaunalee, 2-night trip

8/10 Very good

Good location
mirtha, 2-night trip

10/10 Exceptional

Room comfortable and clean. Staff very helpful and friendly. Loved the art!
Glenn, 1-night trip

8/10 Very good

Bed was comfortable, room was large, bathroom was OK. Staff was kind. Wish the breakfast opened earlier on Sunday.
ABBEY, 3-night trip

10/10 Exceptional

Love my stay at this unique musuem hotel!
Andrea, 1-night trip

10/10 Exceptional

Fun place to stay! Eclectic, unique and eccentric decor. Really enjoyed the location and convenient, walkable access.
Kimberley, 3-night trip