Hotels in Mesopotamia

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May 1 - May 2
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May 2 - May 3
This weekend
May 2 - May 4
Next weekend
May 9 - May 11

Where to stay in Mesopotamia?

To Spiti tis Sofias
Interior

To Spiti tis Sofias

The price is $76
includes taxes & fees
$65 per night
May 14 - May 15
To Spiti tis Sofias
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Mesopotamia

Kastoria Lake

Kastoria Lake is 1.3 mi (2.1 km) from central Kastoria, why not stop by during your stay.

See properties in Kastoria Lake
Kastoria Lake

Learn more about Mesopotamia

The region around Mesopotamia is home to attractions such as Kastoria Lake and Dragon's Lair.

See all hotels in Mesopotamia
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

What hotels do travelers like in Mesopotamia?
Guests like To Spiti tis Sofias, Limneon Resort & Spa and Chloe Hotel.
Can I book a refundable hotel in Mesopotamia?
If you want the flexibility to change your travel plans to Mesopotamia, most hotels offer refundable* bookable rates. You can find these accommodations by searching our site and using the “fully refundable” filter to narrow down the results.
Where can I stay if I'm visiting Mesopotamia with my children?
Your kids are welcome at To Spiti tis Sofias.
What will the weather in Mesopotamia be like during my trip?
The warmest months in Mesopotamia are usually August and July with an average temp of 69°F. January and February are the chilliest months when the average temp is 37°F. The rainiest months are November and December.
Why should I book my Mesopotamia hotel with Hotels.com?
There are plenty of reasons to book your Mesopotamia travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

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