Hotels in Tuscola

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Check prices for these dates

Tonight
Apr 26 - Apr 27
Tomorrow
Apr 27 - Apr 28
Next weekend
May 2 - May 4
In two weeks
May 9 - May 11

Where to stay in Tuscola?

Comfort Inn & Suites Regional Medical Center
Front of property - evening/night

Comfort Inn & Suites Regional Medical Center

2.5 star property
8.4 out of 10, Very Good, (875)
The price is $95
includes taxes & fees
$82 per night
May 18 - May 19
Comfort Inn & Suites Regional Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Tuscola

Abilene State Park

Abilene State Park is 4.8 mi (7.8 km) from central Tuscola, why not stop by during your stay.

See properties in Abilene State Park
Abilene State Park

Learn more about Tuscola

The region around Tuscola is home to attractions such as Abilene State Park and Mall of Abilene.

See all hotels in Tuscola
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

What accommodations do travelers recommend in Tuscola?
Guests like Retreat Abilene | A Retreat DFW Experience, Cozy Cabin and Dug Out Hideaway.
Can I book refundable hotels in Tuscola?
If you need the flexibility to change your plans to Tuscola, most hotels provide refundable* rates you can book. You can see these properties by searching our site and using the “fully refundable” filter to narrow the results down.
What will the weather in Tuscola be like during my trip?
August and July are typically the warmest months in Tuscola when the average temp is 83°F. January and February are the coldest months when the average temperature is 50°F. May and September are the months with the most rain.
Why should I book my Tuscola hotel through Hotels.com?
There are lots of reasons to book your Tuscola trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

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