Hotels in Carlisle

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Tonight
May 5 - May 6
Tomorrow
May 6 - May 7
This weekend
May 9 - May 11
Next weekend
May 16 - May 18

Where to stay in Carlisle?

Sleep Inn & Suites Pleasant Hill - Des Moines
Indoor pool

Sleep Inn & Suites Pleasant Hill - Des Moines

2.5 star property
8.0 out of 10, Very Good, (795)
The price is $80
includes taxes & fees
$71 per night
May 11 - May 12
Sleep Inn & Suites Pleasant Hill - Des Moines
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Carlisle

MercyOne Carlisle Family Medicine

MercyOne Carlisle Family Medicine is a hospital located 1.6 mi (2.6 km) from central Carlisle.

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MercyOne Carlisle Family Medicine

Learn more about Carlisle

The region around Carlisle is home to attractions such as Sleepy Hollow Sports Park and Blank Park Zoo.

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A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

What hotels do travelers recommend in Carlisle?
Guests like Hotel Fort Des Moines, Curio Collection by Hilton, Days Inn & Suites by Wyndham Des Moines Airport and Surety Hotel.
Can I book refundable accommodations in Carlisle?
If you need the flexibility to change your plans to Carlisle, most hotels provide refundable* rates you can book. You can find these properties by searching our site and using the “fully refundable” filter to narrow the results down.
Where can I stay with my pet in Carlisle?
Your furry friend can stay with you at this pet-friendly hotel: 250+ Acre Private Hunting/Fishing Lodge - 5 minutes to city.
Where can I stay if I'm traveling to Carlisle with my family?
Your kids are welcome at 250+ Acre Private Hunting/Fishing Lodge - 5 minutes to city.
What will the weather in Carlisle be like during my visit?
The warmest months in Carlisle are usually July and August with an average temp of 72°F. January and February are the chilliest months when the average temp is 29°F. The rainiest months are May and June.
Why should I book my Carlisle hotel through Hotels.com?
There are lots of reasons to book your Carlisle trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

https://www.hotels.com/lp/b/deals